Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | CTSA | P10619 | 2/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 8/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25807049 | 0.82 | SMYD3 (0.43) | LOXL2SMYD3CTSAANO1PARP1 | |
| SCHEMBL19556414 | 0.77 | AR (0.54) | LOXL2SMYD3ARPARP1CYP4F2 | |
| SCHEMBL30112067 | 0.77 | AR (0.54) | LOXL2SMYD3ARPARP1CYP4F2 | |
| SCHEMBL29684020 | 0.76 | CYP4F2 (0.40) | LOXL2ARCYP4F2CYP4A11 | |
| SCHEMBL25799158 | 0.75 | KDR (0.35) | LOXL2SMYD3ARANO1 | |
| SCHEMBL25797141 | 0.75 | DDR1 (0.49) | LOXL2ANO1 | |
| SCHEMBL25804854 | 0.72 | LRRK2 (0.43) | SMYD3ANO1 | |
| SCHEMBL22627769 | 0.71 | ALDH1A1 (0.38) | ANO1CYP4F2CYP4A11 | |
| SCHEMBL25804972 | 0.69 | KDR (0.36) | SMYD3 | |
| SCHEMBL13945543 | 0.69 | PLK1 (0.51) | LOXL2SMYD3CTSAPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |