Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | ANO1 | Q5XXA6 | 9/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25804972 | 0.82 | KDR (0.36) | KDRKDM1AHDAC1HDAC6NPC1 | |
| SCHEMBL25816056 | 0.82 | KDR (0.38) | KDRKDM1AHDAC1HDAC6ANO1 | |
| SCHEMBL19556320 | 0.77 | AR (0.47) | KDRARKDM1AHDAC1HDAC6 | |
| SCHEMBL19556321 | 0.77 | AR (0.47) | KDRARKDM1AHDAC1HDAC6 | |
| SCHEMBL30112035 | 0.77 | AR (0.47) | KDRARKDM1AHDAC1HDAC6 | |
| SCHEMBL25799171 | 0.75 | LOXL2 (0.40) | ARANO1SMYD3LOXL2 | |
| SCHEMBL22627801 | 0.73 | RXFP1 (0.49) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL25797141 | 0.73 | DDR1 (0.49) | KDRANO1LOXL2DDR1 | |
| SCHEMBL25807049 | 0.72 | SMYD3 (0.43) | ANO1NPC1RAB9ASMYD3LOXL2 | |
| SCHEMBL22956393 | 0.71 | HDAC3 (0.37) | HDAC1HDAC6ANO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |