⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15147441 | 0.83 | ALDH1A1 (0.33) | — | |
| SCHEMBL1954970 | 0.77 | IDO1 (0.45) | — | |
| SCHEMBL13148721 | 0.73 | CYP2A6 (0.57) | — | |
| SCHEMBL409605 | 0.73 | CYP2A6 (0.57) | — | |
| SCHEMBL17223076 | 0.73 | CYP2A6 (0.57) | — | |
| SCHEMBL16526973 | 0.73 | CYP2A6 (0.57) | — | |
| SCHEMBL8990842 | 0.73 | HTT (0.38) | — | |
| SCHEMBL1187788 | 0.71 | — | — | |
| SCHEMBL1103762 | 0.71 | — | — | |
| SCHEMBL18508 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118271323-A | WRN inhibitors | 苏州浦合医药科技有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-109988105-A | Heterocyclic nitrogen compound and preparation method thereof as kinases inhibitor | 天津滨江药物研发有限公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-108658937-A | A kind of bicyclic alkaloid compound and its preparation method and application | 中国海洋大学 | 2018-10-16 | — | — | CN | disclosed |
| CN-108383875-A | A kind of the 3- phosphonomethyls indoline and preparation method of silver catalysis | 昆明学院 | 2018-08-10 | — | — | CN | disclosed |
| CN-105384754-B | Heterocycle compound as kinases inhibitor and its preparation method and application | 上海科州药物研发有限公司 | 2018-04-20 | — | — | CN | disclosed |
| CN-106565625-B | A kind of antiplatelet reduces the preparation method of disease new drug Lusutrombopag intermediates | 杭州励德生物科技有限公司 | 2018-01-30 | — | — | CN | disclosed |
| WO-2017214505-A1 | CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2017-12-14 | — | — | WO | disclosed |
| CN-106565625-A | Preparation method for intermediates of new medicine Lusutrombopag resisting to thrombopenia | 杭州励德生物科技有限公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-104230826-B | 2 fluoro quinazoline cyclics and preparation method thereof and pharmaceutical usage | 复旦大学 | 2017-03-29 | — | — | CN | disclosed |
| CN-105384754-A | Heterocyclic compounds serving as protein kinase inhibitors and preparation method for heterocyclic compounds and application of heterocyclic compounds | KECHOW PHARMA INC | 2016-03-09 | — | — | CN | disclosed |
| CN-103097353-A | Novel immunomodulator and anti-inflammatory compounds | INCOZEN THERAPEUTICS PVT LTD | 2013-05-08 | — | — | CN | disclosed |
| US-8436027-B2 | Azole compounds used as tuberculostatic and leishmanicide agents | Fundacão Oswaldo Cruz—FIOCRUZ (BR) | 2013-05-07 | — | — | US | disclosed |
| EP-2566847-A1 | NOVEL IMMUNOMODULATOR AND ANTI INFLAMMATORY COMPOUNDS | Icozen Therapeutics Pvt. Ltd. (IN) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011138665-A1 | NOVEL IMMUNOMODULATOR AND ANTI INFLAMMATORY COMPOUNDS | INCOZEN THERAPEUTICS PVT. LTD. (IN) | 2011-11-10 | — | — | WO | disclosed |
| US-20110269803-A1 | AZOLE COMPOUNDS USED AS TUBERCULOSTATIC AND LEISHMANICIDE AGENTS | FUNDACAO OSWALDO CRUZ - FIOCRUZ (BR) | 2011-11-03 | — | — | US | disclosed |
| CN-102137837-A | PAI-1 inhibitor | INST MED MOLECULAR DESIGN INC | 2011-07-27 | — | — | CN | disclosed |
| US-20090054501-A1 | AZOLE COMPOUNDS USED AS TUBERCULOSTATIC AND LEISHMANICIDE AGENTS | BOECHAT NUBIA | 2009-02-26 | — | — | US | disclosed |
| EP-1976832-A2 | AZOLE COMPOUNDS USED AS TUBERCULOSTATIC AND LEISHMANICIDE AGENTS | Fundacao Oswaldo Cruz - Fiocruz (BR) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007019660-A2 | AZOLE COMPOUNDS USED AS TUBERCULOSTATIC AND LEISHMANICIDE AGENTS | Fundação Oswaldo Cruz - FIOCRUZ (BR) | 2007-02-22 | — | — | WO | disclosed |
| US-4353734-A | PRE- AND POSTEMERGENCE | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA R.T. (HU) | 1982-10-12 | — | — | US | disclosed |