Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22627589 | 0.88 | TDP1 (0.39) | RXFP1KMT2AHPGDMEN1NPSR1 | |
| SCHEMBL22627852 | 0.88 | TRPV1 (0.43) | RXFP1KMT2AALDH1A1TDP1 | |
| SCHEMBL25808564 | 0.86 | TDP1 (0.52) | KMT2AMEN1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL22627559 | 0.86 | ATF4 (0.41) | ALDH1A1TDP1 | |
| SCHEMBL25812812 | 0.80 | TRPV1 (0.45) | TDP1 | |
| SCHEMBL22627742 | 0.80 | TDP1 (0.51) | KMT2AMEN1TDP1RAB9A | |
| SCHEMBL20999332 | 0.79 | HPGD (0.64) | RXFP1KMT2AHPGDMEN1MAPT | |
| SCHEMBL22956283 | 0.79 | DHODH (0.36) | RXFP1TDP1 | |
| SCHEMBL22956628 | 0.78 | MEN1 (0.58) | RXFP1KMT2AHPGDMEN1MAPT | |
| SCHEMBL25796969 | 0.77 | TDP1 (0.43) | RXFP1KMT2AHPGDMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |