SCHEMBL25809490

SCHEMBL25809490

COc1ccc(CNCCc2ccc(C#N)cc2OC)cc1

nearest known ligand 0.60

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 11/20 0.60
CACNA1G O43497 1/20 0.53
CACNA1B Q00975 1/20 0.53
BCHE P06276 2/20 0.52
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
HTR2C P28335 1/20 0.48
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
GAA P10253 1/20 0.47
CHRM2 P08172 1/20 0.47
ALKBH5 Q6P6C2 1/20 0.46
CHEK1 O14757 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25809489 0.89 HTR2A (0.61) HTR2ACACNA1GCACNA1BBCHEKDM4E
SCHEMBL25809437 0.87 HTR2A (0.63) HTR2ABCHEHTR2CKMT2ACHRM2
SCHEMBL25809444 0.81 HTR2A (0.55) HTR2ABCHEKDM4EALDH1A1HTR2C
SCHEMBL25809486 0.81 HTR2A (0.55) HTR2ABCHEKDM4EHTR2CMEN1
SCHEMBL25809492 0.78 HTR2A (0.56) HTR2AHTR2CKMT2ACHEK1
SCHEMBL25809485 0.78 HTR2A (0.71) HTR2AKDM4EALDH1A1HTR2CMEN1
SCHEMBL25809589 0.76 HTR2A (0.54) HTR2ABCHEKDM4EALDH1A1HTR2C
SCHEMBL25809647 0.76 HTR2A (0.51) HTR2AHTR2CCHEK1
SCHEMBL29633112 0.75 HTR2A (0.76) HTR2AHTR2CCHRM2
SCHEMBL29633061 0.75 HTR2A (0.72) HTR2AKDM4EALDH1A1HTR2CGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023130181-A1 PHENETHLYAMINES AND METHODS OF PREPARATION THEREOF BRIGHT MINDS BIOSCIENCES INC. (CA) 2023-07-13 WO disclosed