Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 5/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30492862 | 1.00 | USP2 (0.54) | USP2SMN1; SMN2NPC1RAB9AMITF | |
| SCHEMBL30492883 | 0.86 | CHRNA7 (0.42) | USP2CHRNA7BCL2L1NR1H4RPA1 | |
| SCHEMBL25810758 | 0.86 | CHRNA7 (0.42) | USP2CHRNA7BCL2L1NR1H4RPA1 | |
| SCHEMBL31025961 | 0.84 | HRH4 (0.49) | SMN1; SMN2NPC1RAB9ACHRNA7BCL2L1 | |
| SCHEMBL25296879 | 0.84 | HRH4 (0.49) | SMN1; SMN2NPC1RAB9ACHRNA7BCL2L1 | |
| SCHEMBL17858475 | 0.83 | IP6K1 (0.50) | SMN1; SMN2NPC1RAB9ATP53CHRNA7 | |
| SCHEMBL30492838 | 0.83 | LGMN (0.47) | USP2SMN1; SMN2NPC1RAB9ACHRNA7 | |
| SCHEMBL25810272 | 0.83 | LGMN (0.47) | USP2SMN1; SMN2NPC1RAB9ACHRNA7 | |
| SCHEMBL30492925 | 0.83 | CHRNA7 (0.46) | CHRNA7BCL2L1MAPTNR1H4KDM4E | |
| SCHEMBL25809845 | 0.83 | CHRNA7 (0.46) | CHRNA7BCL2L1MAPTNR1H4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125376-A1 | FUSED BICYCLIC HETEROARYL AMIDE COMPOUND AS PROTEIN AGGREGATION INHIBITOR | 上海京新生物医药有限公司 | 2023-07-06 | — | — | WO | disclosed |