Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 1/20 | 0.41 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 7/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25810298 | 0.82 | BRAF (0.35) | USP28USP25P2RX3BACE1BACE2 | |
| SCHEMBL25810186 | 0.80 | USP28 (0.45) | USP28USP25P2RX3SSTR4SCD | |
| SCHEMBL25809752 | 0.76 | USP28 (0.42) | USP28USP25P2RX3SSTR4SCD | |
| SCHEMBL25810387 | 0.75 | USP28 (0.41) | USP28USP25P2RX3SSTR4SCD | |
| SCHEMBL25810528 | 0.73 | USP28 (0.39) | USP28USP25P2RX3SSTR4SCD | |
| SCHEMBL25829927 | 0.73 | USP28 (0.38) | USP28USP25SSTR4SCD | |
| SCHEMBL25825955 | 0.71 | USP28 (0.49) | USP28USP25SSTR4LRRK2 | |
| SCHEMBL25830115 | 0.70 | USP28 (0.38) | USP28USP25P2RX3SSTR4SCD | |
| SCHEMBL25810573 | 0.69 | USP28 (0.37) | USP28USP25SSTR4SCD | |
| SCHEMBL25794463 | 0.69 | USP28 (0.69) | USP28USP25RAF1SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122298-A1 | PROTEIN STABILIZING COMPOUNDS CONTAINING USP28 AND/OR USP25 TARGETING LIGANDS | Stablix, Inc. (US) | 2023-06-29 | — | — | WO | disclosed |