Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | BACE1 | P56817 | 6/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.32 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25810296 | 0.82 | USP28 (0.41) | BACE1P2RX3BACE2USP28USP25 | |
| SCHEMBL25810186 | 0.70 | USP28 (0.45) | P2RX3USP28USP25 | |
| SCHEMBL25290787 | 0.68 | TP53 (0.34) | USP28USP25 | |
| SCHEMBL30563485 | 0.68 | TP53 (0.34) | USP28USP25 | |
| SCHEMBL25423502 | 0.68 | STING1 (0.43) | BRAFUSP28USP25ABL1 | |
| SCHEMBL30563276 | 0.68 | STING1 (0.43) | BRAFUSP28USP25ABL1 | |
| SCHEMBL30563296 | 0.67 | USP28 (0.40) | USP28USP25 | |
| SCHEMBL25809752 | 0.67 | USP28 (0.42) | P2RX3USP28USP25 | |
| SCHEMBL25810387 | 0.66 | USP28 (0.41) | P2RX3USP28USP25 | |
| SCHEMBL25810528 | 0.64 | USP28 (0.39) | P2RX3USP28USP25 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122298-A1 | PROTEIN STABILIZING COMPOUNDS CONTAINING USP28 AND/OR USP25 TARGETING LIGANDS | Stablix, Inc. (US) | 2023-06-29 | — | — | WO | disclosed |