Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5928699 | 0.84 | KMT2A (0.78) | KDM4EHSD17B10TSHRGAAKMT2A | |
| SCHEMBL6990712 | 0.84 | KDM4E (0.72) | KDM4EHSD17B10TSHRGAAKMT2A | |
| SCHEMBL31061852 | 0.84 | KDM4E (0.71) | KDM4EHSD17B10TSHRGAAKMT2A | |
| SCHEMBL15209741 | 0.81 | ALDH1A1 (0.67) | KDM4EGAAKMT2AALDH1A1LMNA | |
| SCHEMBL6922153 | 0.80 | HPGD (0.54) | KDM4EHSD17B10TSHRGAAKMT2A | |
| SCHEMBL19910791 | 0.79 | MAPK1 (0.61) | KDM4EKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL15247744 | 0.79 | RAB9A (0.63) | KDM4EHSD17B10TSHRGAAKMT2A | |
| SCHEMBL15209771 | 0.78 | ALDH1A1 (0.60) | KDM4EHSD17B10TSHRGAAKMT2A | |
| SCHEMBL28609648 | 0.78 | HPGD (0.62) | KDM4EGAAKMT2AALDH1A1LMNA | |
| SCHEMBL15220716 | 0.77 | ALDH1A1 (0.59) | KDM4EHSD17B10TSHRKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |