Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5928699 | 0.87 | KMT2A (0.78) | KDM4EPOLBHSD17B10TSHRKMT2A | |
| SCHEMBL31061852 | 0.87 | KDM4E (0.71) | KDM4EPOLBHCAR2HSD17B10TSHR | |
| SCHEMBL25811369 | 0.84 | KDM4E (0.65) | KDM4EPOLBHCAR2HSD17B10TSHR | |
| SCHEMBL9361352 | 0.84 | KDM4E (1.00) | KDM4EPOLBHCAR2HSD17B10TSHR | |
| SCHEMBL6998424 | 0.84 | ALDH1A1 (0.76) | KDM4EPOLBHCAR2HSD17B10TSHR | |
| SCHEMBL20840643 | 0.84 | KMT2A (0.60) | KDM4EPOLBHCAR2KMT2AALDH1A1 | |
| SCHEMBL10634666 | 0.83 | KDM4E (0.68) | KDM4EPOLBHCAR2HSD17B10TSHR | |
| SCHEMBL12879817 | 0.83 | KMT2A (0.69) | KDM4EPOLBHCAR2HSD17B10TSHR | |
| SCHEMBL9365066 | 0.83 | KDM4E (0.67) | KDM4EPOLBHCAR2HSD17B10TSHR | |
| SCHEMBL8689332 | 0.82 | HCAR2 (1.00) | KDM4EPOLBHCAR2HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980374-B1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PFIZER HOLDING FRANCE (FR) | 2003-02-12 | — | — | EP | disclosed |
| US-6239130-B1 | ASTHMA, ATOPIC DERMATITIS, RHEUMATOID ARTHRITIS, INFLAMMATORY BOWEL DISORDERS, PULMONARY HYPERTENSION, LIVER INJURY, BONE LOSS, SEPTIC SHOCK, OR MULTIPLE SCLEROSIS, | WARNER-LAMBERT COMPANY | 2001-05-29 | — | — | US | disclosed |
| EP-0980374-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998049169-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 1998-11-05 | — | — | WO | disclosed |