Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | RAD52 | P43351 | 2/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25811418 | 0.90 | POLB (0.53) | MAPTALDH1A1POLBMAPK1RAD52 | |
| SCHEMBL69334 | 0.88 | CA12 (0.56) | MAPTALDH1A1POLBMAPK1HCRTR1 | |
| SCHEMBL21355204 | 0.85 | MAPT (0.54) | MAPTALDH1A1POLBMAPK1RAD52 | |
| SCHEMBL10853593 | 0.83 | HCRTR1 (0.50) | MAPTALDH1A1POLBMAPK1RAD52 | |
| SCHEMBL2162546 | 0.82 | MEN1 (0.61) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5323335 | 0.81 | KDM4E (0.64) | MAPTALDH1A1HCRTR1KDM4EHPGD | |
| SCHEMBL14744847 | 0.81 | MAPT (0.55) | MAPTALDH1A1POLBMAPK1RAD52 | |
| SCHEMBL22134576 | 0.80 | CA12 (0.48) | MAPTALDH1A1POLBMAPK1HCRTR1 | |
| SCHEMBL1586533 | 0.80 | KDM4E (0.61) | MAPTALDH1A1POLBMAPK1RAD52 | |
| SCHEMBL7662422 | 0.80 | MAPT (0.54) | MAPTALDH1A1POLBMAPK1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218573-A1 | INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | GALYAN BIO INC (US) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230218573-A1 | INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | HTT, HYPK, PARK7 | MAPT 18/4885ALDH1A1 4430/4885POLB 2897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.