Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 7/20 | 0.52 |
| ▸ | TDO2 | P48775 | 7/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1144985 | 0.88 | KDM4E (0.77) | KDM4EHPGDIDO1TDO2HRH4 | |
| SCHEMBL30310687 | 0.87 | KDM4E (0.57) | KDM4EHPGDIDO1TDO2HRH4 | |
| SCHEMBL20505200 | 0.87 | KDM4E (0.57) | KDM4EHPGDIDO1TDO2HRH4 | |
| SCHEMBL4407742 | 0.83 | KDM4E (0.60) | KDM4EHPGDHRH4KMT2AMEN1 | |
| SCHEMBL24019767 | 0.82 | KDM4E (0.52) | KDM4EHPGDIDO1TDO2HRH4 | |
| SCHEMBL1144707 | 0.82 | KDM4E (0.52) | KDM4EHPGDIDO1TDO2HRH4 | |
| SCHEMBL22407908 | 0.76 | KDM4E (0.42) | KDM4EHPGDIDO1TDO2KMT2A | |
| SCHEMBL24136190 | 0.74 | HPGD (0.41) | KDM4EHPGDIDO1TDO2KMT2A | |
| SCHEMBL29824959 | 0.74 | KDM4E (1.00) | KDM4EHPGDIDO1TDO2KMT2A | |
| SCHEMBL3602542 | 0.74 | KDM4E (1.00) | KDM4EHPGDIDO1TDO2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. | 2023-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | CTRL, CTSL, CTSV | KDM4E 3122/4885HPGD 1219/4885IDO1 1859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.