Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.39 |
| ▸ | TDO2 | P48775 | 3/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.36 |
| ▸ | TUBB | P07437 | 2/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24136182 | 0.82 | KDM4E (0.44) | HPGDKDM4ENQO1TUBB1TUBB4A | |
| SCHEMBL22407908 | 0.81 | KDM4E (0.42) | HPGDKDM4EIDO1TDO2NQO1 | |
| SCHEMBL24136219 | 0.77 | ADRA2A (0.38) | KDM4EIDO1TDO2ALDH1A1CYP1A2 | |
| SCHEMBL24136220 | 0.76 | IDO1 (0.36) | KDM4EIDO1TDO2ALDH1A1TSHR | |
| SCHEMBL29952109 | 0.76 | HPGD (0.42) | HPGDKDM4EIDO1TDO2TUBB1 | |
| SCHEMBL20504720 | 0.76 | IMPDH2 (0.39) | HPGDKDM4EIDO1TDO2NQO1 | |
| SCHEMBL25812174 | 0.74 | KDM4E (0.59) | HPGDKDM4EIDO1TDO2TUBB1 | |
| SCHEMBL1144985 | 0.74 | KDM4E (0.77) | HPGDKDM4EIDO1TDO2TUBB1 | |
| SCHEMBL20505200 | 0.73 | KDM4E (0.57) | HPGDKDM4EIDO1TDO2TUBB1 | |
| SCHEMBL30310687 | 0.73 | KDM4E (0.57) | HPGDKDM4EIDO1TDO2TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3928836-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2021-12-29 | — | — | EP | disclosed |