Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 15/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.37 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25812815 | 0.94 | ATF4 (0.51) | ATF4PTPRCPTPN1PTPN11PTPN13 | |
| SCHEMBL19568855 | 0.86 | ATF4 (0.43) | ATF4PTPRCPTPN1PTPN11PTPN13 | |
| SCHEMBL19556468 | 0.85 | ATF4 (0.51) | ATF4TRPV1 | |
| SCHEMBL25804693 | 0.84 | ATF4 (0.50) | ATF4 | |
| SCHEMBL19568400 | 0.81 | SSTR3 (0.44) | ATF4ALDH1A1HPGDTSHRGAA | |
| SCHEMBL22437135 | 0.81 | ATF4 (0.40) | ATF4PTPRCPTPN1PTPN11PTPN13 | |
| SCHEMBL25796804 | 0.80 | ATF4 (0.53) | ATF4PTPRCPTPN1PTPN11PTPN13 | |
| SCHEMBL20992779 | 0.79 | ATF4 (0.44) | ATF4 | |
| SCHEMBL22437091 | 0.79 | ATF4 (0.54) | ATF4 | |
| SCHEMBL19556276 | 0.79 | ATF4 (0.61) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |