Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR3 | P32745 | 2/20 | 0.44 |
| ▸ | ATF4 | P18848 | 9/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569374 | 0.84 | ATF4 (0.50) | ATF4 | |
| SCHEMBL25812808 | 0.83 | ALDH1A1 (0.46) | ATF4ALDH1A1HPGDTSHRGAA | |
| SCHEMBL25804759 | 0.82 | RXFP1 (0.43) | ATF4ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL19556113 | 0.82 | ATF4 (0.57) | ATF4MRGPRX4ALDH1A1ADAMTS5GAA | |
| SCHEMBL25812962 | 0.81 | ATF4 (0.43) | ATF4ALDH1A1HPGDTSHRGAA | |
| SCHEMBL20992251 | 0.81 | ATF4 (0.49) | ATF4TSHRGAA | |
| SCHEMBL20992524 | 0.81 | ATF4 (0.51) | SSTR3ATF4MEN1KMT2A | |
| SCHEMBL20992410 | 0.80 | ATF4 (0.50) | ATF4 | |
| SCHEMBL19568855 | 0.80 | ATF4 (0.43) | ATF4ALDH1A1HPGDTSHRMEN1 | |
| SCHEMBL19568607 | 0.80 | ATF4 (0.50) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193063-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |