Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 12/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.38 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25813024 | 0.88 | ATF4 (0.40) | ATF4HCRTR1ALDH1A1HPGDTSHR | |
| SCHEMBL25796964 | 0.88 | ATF4 (0.40) | ATF4HCRTR1ALDH1A1HPGDTSHR | |
| SCHEMBL25812808 | 0.86 | ALDH1A1 (0.46) | ATF4KMT2AALDH1A1HPGDTSHR | |
| SCHEMBL25812962 | 0.86 | ATF4 (0.43) | ATF4PTPRCPTPN1PTPN11PTPN13 | |
| SCHEMBL19555896 | 0.85 | ATF4 (0.52) | ATF4 | |
| SCHEMBL25804759 | 0.83 | RXFP1 (0.43) | ATF4MEN1KMT2AALDH1A1 | |
| SCHEMBL20992455 | 0.83 | ATF4 (0.50) | ATF4 | |
| SCHEMBL25781454 | 0.82 | ALDH1A1 (0.37) | ATF4HCRTR1KMT2AALDH1A1 | |
| SCHEMBL20992677 | 0.81 | ATF4 (0.49) | ATF4 | |
| SCHEMBL19568400 | 0.80 | SSTR3 (0.44) | ATF4MEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193063-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |