Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.47 |
| ▸ | CHKA | P35790 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.41 |
| ▸ | TERT | O14746 | 2/20 | 0.41 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23451281 | 0.73 | HRH4 (0.47) | HRH4TRIM24TRIM33CHKAALDH1A1 | |
| SCHEMBL6167866 | 0.73 | HRH4 (0.47) | HRH4CHKAALDH1A1KDM4EMAPT | |
| SCHEMBL6167874 | 0.73 | HRH4 (0.47) | HRH4CHKAALDH1A1KDM4EMAPT | |
| SCHEMBL9056991 | 0.73 | MAPT (0.37) | ALDH1A1KDM4ESMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL2600020 | 0.73 | TRIM24 (0.53) | TRIM24TRIM33CHKAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL7260366 | 0.72 | HRH4 (0.46) | HRH4CHKAALDH1A1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL7260368 | 0.72 | HRH4 (0.46) | HRH4CHKAALDH1A1KDM4EMAPT | |
| SCHEMBL24532577 | 0.72 | IP6K1 (0.54) | HRH4TRIM24TRIM33ALDH1A1KDM4E | |
| SCHEMBL1634508 | 0.72 | CHKA (0.52) | HRH4CHKAALDH1A1MAPTIP6K1 | |
| SCHEMBL24126771 | 0.72 | CHKA (0.52) | HRH4CHKAALDH1A1MAPTIP6K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |