Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.51 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.50 |
| ▸ | TERT | O14746 | 3/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | S100B | P04271 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29529691 | 0.98 | HRH4 (0.54) | CHKAHRH4ELOVL1TERTDHFR | |
| SCHEMBL21807915 | 0.83 | HRH4 (0.59) | HRH4MEN1GAAMAPTMAPK1 | |
| SCHEMBL21807926 | 0.83 | LMNA (0.46) | MEN1ALDH1A1LMNAMAPTALOX15 | |
| SCHEMBL31051506 | 0.83 | LMNA (0.46) | MEN1ALDH1A1LMNAMAPTALOX15 | |
| SCHEMBL31051504 | 0.83 | HRH4 (0.59) | HRH4MEN1GAAMAPTMAPK1 | |
| SCHEMBL27102997 | 0.83 | ADRB2 (0.56) | HRH4ALDH1A1MAPTHTT | |
| Hydrochloric Acid SCHEMBL23302654 | 0.82 | ADRB2 (0.55) | HRH4ALDH1A1MAPTHTT | |
| Hydrochloric Acid SCHEMBL29882400 | 0.82 | ADRB2 (0.55) | HRH4ALDH1A1MAPTHTT | |
| SCHEMBL24126677 | 0.77 | ACHE (0.41) | HRH4 | |
| SCHEMBL27106846 | 0.77 | WNT3A (0.52) | MEN1GAAMAPTALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107624113-A | Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2018-01-23 | — | — | CN | claimed |
| WO-2021256569-A1 | CONDENSED RING COMPOUNDS THAT INHIBIT H-PGDS | 佐藤製薬株式会社 | 2021-12-23 | — | — | WO | disclosed |
| CN-107624113-A | Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2018-01-23 | — | — | CN | disclosed |
| EP-2948442-B1 | PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2016-10-26 | — | — | EP | disclosed |
| WO-2014114578-A1 | PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-31 | — | — | WO | disclosed |