SCHEMBL25813368

SCHEMBL25813368

CC(=O)Nc1c(C)c(C(=O)Cl)c(C)c(C(=O)Cl)c1C

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.37
ALDH1A1 P00352 5/20 0.36
TDP1 Q9NUW8 1/20 0.34
HPGD P15428 3/20 0.33
HSD17B10 Q99714 3/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
PTPRB P23467 1/20 0.33
GAA P10253 2/20 0.32
PKM P14618 2/20 0.32
ALOX15 P16050 1/20 0.31
HTT P42858 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
NAPRT Q6XQN6 1/20 0.31
TSHR P16473 2/20 0.31
MAPT P10636 2/20 0.31
COPS5 Q92905 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22661238 0.87 LMNA (0.47) LMNAALDH1A1SMN1; SMN2
SCHEMBL4163347 0.78 ALDH1A1 (0.39) ALDH1A1TSHR
SCHEMBL22681066 0.78 LMNA (0.50) LMNAALDH1A1TDP1HPGDHSD17B10
SCHEMBL14156046 0.77 ALDH1A1 (0.30) ALDH1A1
SCHEMBL13103938 0.76 ALDH1A1 (0.47) LMNAALDH1A1TDP1HPGDHSD17B10
SCHEMBL20882091 0.76 LMNA (0.42) LMNAALDH1A1TDP1HPGDHSD17B10
SCHEMBL14435485 0.75 SMN1; SMN2 (0.45) LMNAALDH1A1HPGDHSD17B10L3MBTL1
SCHEMBL2154609 0.72 ALDH1A1 (0.39) ALDH1A1TSHR
SCHEMBL3082732 0.72 LMNA (0.63) LMNAHSD17B10L3MBTL1GAAPKM
SCHEMBL9688739 0.71 LMNA (0.35) LMNAALDH1A1HPGDHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023117667-A1 PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODOISOPHTHALIC BISAMIDES BRACCO IMAGING SPA (IT) 2023-06-29 WO disclosed