Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.56 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25811321 | 0.85 | KDM4E (0.51) | KDM4EALDH1A1THRBHPGDHCRTR1 | |
| SCHEMBL25811801 | 0.82 | KMT2A (0.61) | KDM4EALDH1A1THRBHPGDHCRTR1 | |
| SCHEMBL25811987 | 0.82 | KMT2A (0.58) | KDM4EALDH1A1THRBHPGDHCRTR1 | |
| SCHEMBL25814483 | 0.79 | ALDH1A1 (0.53) | KDM4EALDH1A1THRBHPGDHCRTR1 | |
| SCHEMBL25811225 | 0.79 | MAPT (0.68) | KDM4EALDH1A1THRBHPGDTLR9 | |
| SCHEMBL25813335 | 0.76 | TLR8 (0.53) | KDM4EALDH1A1HPGDHCRTR1TLR9 | |
| SCHEMBL25815092 | 0.76 | KDM4E (0.59) | KDM4EALDH1A1TLR9TLR8TLR7 | |
| SCHEMBL25813810 | 0.76 | KDM4E (0.56) | KDM4EALDH1A1TLR9TLR8TLR7 | |
| SCHEMBL2161737 | 0.75 | MAPT (0.50) | KDM4EALDH1A1THRBHPGDHCRTR1 | |
| SCHEMBL14211006 | 0.75 | KDM4E (0.75) | KDM4EALDH1A1THRBHPGDHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218573-A1 | INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | GALYAN BIO INC (US) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230218573-A1 | INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | HTT, HYPK, PARK7 | KDM4E 1465/4885ALDH1A1 4430/4885THRB 2088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.