Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419252 | 0.88 | MAPT (0.52) | MAPTTP53SMN1; SMN2IGF1RHTR1A | |
| SCHEMBL27398024 | 0.88 | MAPT (0.47) | MAPTTP53SMN1; SMN2KDM4EIGF1R | |
| SCHEMBL27358355 | 0.85 | KDM4E (0.46) | MAPTTP53SMN1; SMN2KDM4EIGF1R | |
| SCHEMBL1127846 | 0.84 | MAPT (0.56) | MAPTTP53SMN1; SMN2KDM4EIGF1R | |
| SCHEMBL13419227 | 0.83 | MAPT (0.53) | MAPTTP53SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL25815151 | 0.82 | KDM4E (0.44) | MAPTTP53SMN1; SMN2KDM4EIGF1R | |
| SCHEMBL21164677 | 0.81 | TSHR (0.58) | MAPTTP53IGF1RHTR1ADRD2 | |
| SCHEMBL24663858 | 0.80 | ADRA1D (0.49) | MAPTSMN1; SMN2KDM4EADRA1BADRA1D | |
| SCHEMBL13419225 | 0.80 | KCNH2 (0.44) | MAPTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20363922 | 0.79 | SLC6A2 (0.46) | MAPTTP53HTR1ADRD2ADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129506-A1 | POTENT AND SELECTIVE SMARCA2 DEGRADING CHIMERIC MOLECULES AS CANCER THERAPEUTICS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-07-06 | — | — | WO | disclosed |