Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.45 |
| ▸ | TMPRSS15 | P98073 | 5/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL30338793 | 0.91 | KDM4E (0.43) | KDM4ELMNAPTPN11TMPRSS15NEK2 | |
| SCHEMBL25253979 | 0.86 | KDM4E (0.55) | KDM4EPTPN11TMPRSS15NEK2MEN1 | |
| SCHEMBL30547531 | 0.86 | KDM4E (0.55) | KDM4EPTPN11TMPRSS15NEK2MEN1 | |
| SCHEMBL25816759 | 0.82 | BTK (0.37) | KDM4EPTPN11 | |
| Trifluoroacetic Acid SCHEMBL30339273 | 0.81 | KDM4E (0.49) | KDM4ELMNAPTPN11NEK2HSD17B10 | |
| SCHEMBL25816593 | 0.79 | PTPN11 (0.51) | KDM4ELMNAPTPN11TMPRSS15NEK2 | |
| SCHEMBL30547536 | 0.79 | PTPN11 (0.51) | KDM4ELMNAPTPN11TMPRSS15NEK2 | |
| SCHEMBL18255043 | 0.79 | KDM4E (0.58) | KDM4ELMNAPTPN11NEK2MEN1 | |
| SCHEMBL25816539 | 0.78 | KDM4E (0.51) | KDM4ELMNATMPRSS15MEN1KMT2A | |
| SCHEMBL18255044 | 0.75 | KDM4E (0.57) | KDM4ELMNANEK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| US-20230219937-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-07-13 | — | — | US | disclosed |
| US-20230219937-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-07-13 | — | — | US | disclosed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219937-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | RIPK1, RIPK4, RIPK2 | KDM4E 2270/4885LMNA 4497/4885PTPN11 1535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.