⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26246996 | 0.87 | HRH3 (0.32) | — | |
| SCHEMBL25833072 | 0.78 | NCF1 (0.31) | — | |
| SCHEMBL25730176 | 0.78 | SIGMAR1 (0.32) | — | |
| SCHEMBL23806902 | 0.77 | CYP2D6 (0.44) | — | |
| SCHEMBL25833008 | 0.76 | EPHX1 (0.34) | — | |
| SCHEMBL25468601 | 0.75 | CYP2D6 (0.38) | — | |
| SCHEMBL23945809 | 0.75 | — | — | |
| SCHEMBL22856408 | 0.74 | NAMPT (0.36) | — | |
| SCHEMBL25728446 | 0.74 | ALDH1A1 (0.31) | — | |
| SCHEMBL24764434 | 0.73 | ALDH1A1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807636-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-20230219945-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-07-13 | — | — | US | disclosed |
| US-20230132715-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-05-04 | — | — | US | disclosed |