Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL511339 | 0.94 | NOS2 (0.43) | KCNH2TDP1L3MBTL1NOS2HRH3 | |
| SCHEMBL295055 | 0.85 | NOS1 (0.39) | NOS2CYP2D6HRH1 | |
| SCHEMBL10834770 | 0.83 | CYP2D6 (0.38) | NOS2CYP2D6HRH1 | |
| SCHEMBL4685578 | 0.81 | KCNH2 (0.32) | KCNH2CYP2D6HRH1 | |
| SCHEMBL22877896 | 0.79 | CYP2D6 (0.34) | TDP1CYP2D6HRH1MEN1KMT2A | |
| SCHEMBL22616936 | 0.78 | KCNH2 (0.46) | KCNH2TDP1L3MBTL1NOS2HRH3 | |
| SCHEMBL23138935 | 0.78 | KCNH2 (0.35) | KCNH2 | |
| SCHEMBL105987 | 0.76 | — | — | |
| SCHEMBL5302424 | 0.75 | CYP2D6 (0.35) | NOS2CYP2D6HRH1MEN1KMT2A | |
| SCHEMBL24618582 | 0.75 | HRH4 (0.36) | TDP1NOS2HRH3HRH4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131868-A1 | HETEROCYCLIC INHIBITORS OF GLUT9 FOR TREATMENT OF DISEASE | HORIZON THERAPEUTICS IRELAND DAC (IE) | 2023-07-13 | — | — | WO | disclosed |