Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.60 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.48 |
| ▸ | USP1 | O94782 | 1/20 | 0.46 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.44 |
| ▸ | GRK6 | P43250 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25818900 | 0.87 | NTRK1 (0.58) | NTRK1RAD52KDM4EALDH1A1LMNA | |
| SCHEMBL25818886 | 0.87 | NTRK1 (0.58) | NTRK1CTNNB1TCF7L2RAD52KDM4E | |
| SCHEMBL2203869 | 0.76 | NTRK1 (0.67) | NTRK1CTNNB1TCF7L2USP1WDR48 | |
| SCHEMBL25818909 | 0.75 | NTRK1 (1.00) | NTRK1GRK6PLK4 | |
| SCHEMBL31471730 | 0.74 | NTRK1 (0.79) | NTRK1 | |
| SCHEMBL20352461 | 0.74 | LMNA (0.40) | ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL2204282 | 0.73 | NTRK1 (0.63) | NTRK1CTNNB1TCF7L2USP1WDR48 | |
| SCHEMBL22054938 | 0.73 | WHR1 (0.46) | LMNAMAPTKMT2ANPSR1BCHE | |
| SCHEMBL21567312 | 0.72 | ACHE (0.77) | NTRK1CTNNB1TCF7L2USP1WDR48 | |
| SCHEMBL30092903 | 0.72 | ACHE (0.77) | NTRK1CTNNB1TCF7L2USP1WDR48 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023123883-A1 | METHOD FOR PREPARING QUINAZOLINE DERIVATIVE AND ANALOG THEREOF AND USE THEREOF | 沈阳药科大学 | 2023-07-06 | — | — | WO | disclosed |