Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 6/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29432664 | 0.81 | IDH1 (0.47) | IDH1TGFBR1NFE2L2BTKALDH1A1 | |
| SCHEMBL506568 | 0.81 | IDH1 (0.47) | IDH1TGFBR1NFE2L2BTKALDH1A1 | |
| SCHEMBL22578203 | 0.78 | IDH1 (0.41) | IDH1TGFBR1NFE2L2BTKAPP | |
| SCHEMBL22578205 | 0.78 | IDH1 (0.41) | IDH1TGFBR1NFE2L2BTKAPP | |
| SCHEMBL9000609 | 0.78 | TGFBR1 (0.44) | IDH1TGFBR1NFE2L2APPALDH1A1 | |
| SCHEMBL28873288 | 0.77 | IDH1 (0.43) | IDH1TGFBR1NFE2L2BTKAPP | |
| SCHEMBL1225317 | 0.76 | KDM4E (0.49) | IDH1TGFBR1ALDH1A1LMNAMAPK1 | |
| SCHEMBL4584461 | 0.76 | KDM4E (0.51) | IDH1TGFBR1NFE2L2APPLMNA | |
| SCHEMBL4584462 | 0.76 | KDM4E (0.51) | IDH1TGFBR1NFE2L2APPLMNA | |
| SCHEMBL1225315 | 0.76 | KDM4E (0.49) | IDH1TGFBR1ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219937-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219937-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | RIPK1, RIPK4, RIPK2 | IDH1 4021/4885TGFBR1 1113/4885NFE2L2 3756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.