Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 4/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24475418 | 0.91 | HRH3 (0.46) | HRH3KCNH2DRD2DRD3CYP2D6 | |
| SCHEMBL26295527 | 0.87 | FAAH (0.46) | HRH3KCNH2DRD2DRD3CYP2D6 | |
| SCHEMBL26295701 | 0.85 | HRH3 (0.48) | HRH3KCNH2DRD2DRD3CYP2D6 | |
| SCHEMBL22520620 | 0.85 | MAOB (0.42) | HRH3KCNH2DRD2DRD3MAOB | |
| SCHEMBL26295662 | 0.84 | HRH3 (0.48) | HRH3KCNH2DRD2DRD3CYP2D6 | |
| SCHEMBL18705111 | 0.82 | HRH3 (0.48) | HRH3KCNH2CYP2D6PIK3CD | |
| SCHEMBL26295530 | 0.82 | FAAH (0.43) | HRH3KCNH2DRD2DRD3CYP2D6 | |
| SCHEMBL26494241 | 0.81 | HRH3 (0.41) | HRH3KCNH2DRD2DRD3CYP2D6 | |
| SCHEMBL26263460 | 0.81 | CHRM1 (0.42) | HRH3DRD2DRD3CCR5HTR7 | |
| SCHEMBL25075012 | 0.81 | HSD11B1 (0.42) | HRH3KCNH2DRD2DRD3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A9 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |