Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TLR4 | O00206 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30135714 | 1.00 | ENPP2 (0.38) | ENPP2ATXN2CHRM4SYKHTR1A | |
| SCHEMBL25819509 | 0.83 | CHRM4 (0.44) | ENPP2ATXN2CHRM4SYKCTSL | |
| SCHEMBL30965622 | 0.82 | ENPP2 (0.37) | ENPP2ATXN2CHRM4CTSLCTSB | |
| SCHEMBL30965819 | 0.81 | SYK (0.39) | CHRM4SYKHTR1ADRD2HTR2A | |
| SCHEMBL30965621 | 0.81 | CHRM4 (0.39) | ENPP2ATXN2CHRM4CRBNDDB1 | |
| SCHEMBL25819512 | 0.80 | CHRM4 (0.48) | ENPP2ATXN2CHRM4SYKCTSL | |
| SCHEMBL25035184 | 0.80 | CRBN (0.39) | CRBNDDB1IKZF3 | |
| SCHEMBL30135969 | 0.79 | CHRM4 (0.42) | ENPP2ATXN2CHRM4CTSLCTSB | |
| SCHEMBL25819513 | 0.78 | CHRM4 (0.44) | CHRM4CTSLCTSBCTSKALDH1A1 | |
| SCHEMBL25819521 | 0.77 | CHRM4 (0.45) | ENPP2ATXN2CHRM4CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912710-B2 | Substituted pyrimido[4,5-b][1,4]diazepines as PLK1 degradation inducers | UPPTHERA, INC. (KR) | 2024-02-27 | — | — | US | disclosed |
| US-20230219966-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219966-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | PLK1, BUB1B, BUB1 | ENPP2 1565/4885ATXN2 2262/4885CHRM4 4481/4885 |
| US-11912710-B2 | Substituted pyrimido[4,5-b][1,4]diazepines as PLK1 degradation inducers | PLK1, BUB1B, BUB1 | ENPP2 2034/4885ATXN2 1927/4885CHRM4 4192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.