Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | GLS | O94925 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241330 | 0.95 | PDE9A (0.41) | PDE9APDE10ACHRNB1CHRNB2CHRNB4 | |
| SCHEMBL12147777 | 0.92 | PDE10A (0.40) | PDE9APDE10ACHRNB1CHRNB2CHRNB4 | |
| SCHEMBL12255484 | 0.84 | GBA1 (0.51) | PDE9AKCNH2HRH3 | |
| SCHEMBL20037887 | 0.84 | TLR7 (0.43) | PDE9APDE10ATSHR | |
| SCHEMBL21358975 | 0.82 | EED (0.49) | PDE9ACHRNB2CHRNA4KCNH2HRH3 | |
| SCHEMBL21358974 | 0.82 | EED (0.49) | PDE9ACHRNB2CHRNA4KCNH2HRH3 | |
| SCHEMBL30962118 | 0.82 | EED (0.49) | PDE9ACHRNB2CHRNA4KCNH2HRH3 | |
| SCHEMBL2990172 | 0.80 | CHRNB2 (0.39) | PDE9APDE10ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20038459 | 0.79 | LTA4H (0.42) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20281864 | 0.78 | HRH4 (0.45) | CHRNB2CHRNA4KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212523-A1 | PYRAZOLE AMIDE COMPOUNDS AS IRAK INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2023-07-19 | — | — | EP | disclosed |