Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25825559 | 0.75 | CHRNA7 (0.36) | CHRNA7ALDH1A1PIK3CAMTORNPC1 | |
| SCHEMBL11994370 | 0.74 | CYP1A2 (0.46) | CHRNA7ALDH1A1BACE1KMT2ARXRA | |
| SCHEMBL18542888 | 0.73 | RXRA (0.35) | CHRNA7ALDH1A1BACE1RXRAGRIN1 | |
| SCHEMBL21705891 | 0.73 | RXRA (0.35) | CHRNA7ALDH1A1BACE1RXRAGRIN1 | |
| SCHEMBL3507581 | 0.73 | TLR9 (0.38) | CHRNA7ALDH1A1BACE1SMN1; SMN2RXRA | |
| SCHEMBL5108681 | 0.73 | JAK2 (0.46) | CHRNA7ALDH1A1BACE1RXRAGRIN1 | |
| SCHEMBL12120617 | 0.73 | RXRA (0.35) | CHRNA7ALDH1A1BACE1SMN1; SMN2RXRA | |
| SCHEMBL16175812 | 0.72 | TYR (0.40) | CHRNA7ALDH1A1BACE1KMT2ASMN1; SMN2 | |
| SCHEMBL6637270 | 0.72 | ALDH1A1 (0.37) | CHRNA7ALDH1A1BACE1KMT2ASMN1; SMN2 | |
| SCHEMBL13533992 | 0.72 | KDM4E (0.50) | ALDH1A1RXRAGRIN1GRIN2BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | CHRNA7 4364/4885ALDH1A1 3871/4885PIK3CA 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.