Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 5/20 | 0.45 |
| ▸ | CCNC | P24863 | 3/20 | 0.45 |
| ▸ | GAK | O14976 | 2/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.43 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.43 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25820092 | 0.85 | GABRA1 (0.34) | CDK8CCNCGAKRIPK2COQ8A | |
| SCHEMBL25821117 | 0.84 | CDK8 (0.38) | CDK8CCNCGAKRIPK2COQ8A | |
| SCHEMBL25820090 | 0.83 | TRPV1 (0.38) | CDK8CCNCGAKRIPK2COQ8A | |
| SCHEMBL25821116 | 0.80 | MAP3K14 (0.38) | CDK8GAKRIPK2COQ8ANLK | |
| SCHEMBL25820095 | 0.78 | HTR1A (0.51) | SLC22A12IRAK4 | |
| SCHEMBL3400497 | 0.78 | CDK8 (0.49) | CDK8CCNCGAKRIPK2COQ8A | |
| SCHEMBL21138128 | 0.77 | GAK (0.46) | CDK8CCNCGAKRIPK2COQ8A | |
| SCHEMBL25820130 | 0.77 | KDM4E (0.43) | SLC22A12ATM | |
| SCHEMBL25820075 | 0.77 | CCNC (0.42) | CDK8CCNCGAKAAK1 | |
| SCHEMBL3400496 | 0.75 | GAK (0.44) | CDK8CCNCGAKRIPK2COQ8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
| US-20230183226-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183226-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | CDK8 567/4885CCNC 821/4885GAK 505/4885 |
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | CDK8 385/4885CCNC 491/4885GAK 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.