Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2582670 | 0.84 | KMT2A (0.55) | NPC1KMT2AALDH1A1 | |
| SCHEMBL4261756 | 0.78 | GRM5 (0.48) | GRM5NPC1KMT2A | |
| SCHEMBL2588611 | 0.77 | SMN1; SMN2 (0.67) | NAMPTNPC1KMT2AALDH1A1 | |
| SCHEMBL5529310 | 0.76 | GRM5 (0.46) | GRM5 | |
| SCHEMBL15492432 | 0.75 | HPGDS (0.43) | GRM5NAMPTNPC1KMT2AALDH1A1 | |
| SCHEMBL13194712 | 0.75 | RYR2 (0.36) | NPC1KMT2AALDH1A1 | |
| SCHEMBL20424296 | 0.74 | MEN1 (0.35) | NPC1KMT2AALDH1A1 | |
| SCHEMBL15490051 | 0.72 | NAMPT (0.40) | NAMPTNPC1KMT2AALDH1A1 | |
| SCHEMBL13315137 | 0.72 | GRM5 (0.73) | GRM5NPC1KMT2AALDH1A1 | |
| SCHEMBL17877276 | 0.71 | BRD4 (0.71) | GRM5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |
| US-20090076001-A1 | Substituted 4,5,6,7 -Tetrahydro-Isoxazolo[4,5-C]Pyridine Compounds and Use Thereof for Producing Medicaments | GRUENENTHAL GMBH (DE) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076001-A1 | Substituted 4,5,6,7 -Tetrahydro-Isoxazolo[4,5-C]Pyridine Compounds and Use Thereof for Producing Medicaments | P2RX5, P2RX4, P2RX7 | GRM5 130/4885NAMPT 911/4885NPC1 1245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.