Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4259737 | 0.83 | PKM (0.48) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2588885 | 0.83 | PKM (0.55) | ALDH1A1LMNAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL2581162 | 0.82 | RAB9A (0.58) | ALDH1A1MAPK1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2584665 | 0.79 | NPC1 (0.48) | RAB9ASMN1; SMN2NPC1MAPTGAA | |
| SCHEMBL2589382 | 0.79 | LMNA (0.53) | ALDH1A1LMNAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL2582290 | 0.79 | P2RY12 (0.41) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2582179 | 0.78 | RAB9A (0.47) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL2578684 | 0.77 | KDM4E (0.42) | ALDH1A1LMNAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL2588829 | 0.76 | MAPT (0.48) | ALDH1A1LMNARAB9ANPC1MAPT | |
| SCHEMBL5529341 | 0.76 | PKM (0.47) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |