Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25826829 | 0.76 | ALDH1A1 (0.32) | SMN1; SMN2 | |
| SCHEMBL25826837 | 0.76 | ALDH1A1 (0.32) | SMN1; SMN2 | |
| SCHEMBL25826836 | 0.76 | ALDH1A1 (0.32) | SMN1; SMN2 | |
| SCHEMBL15884857 | 0.74 | ROCK2 (0.36) | SMN1; SMN2NPC1RAB9AATMGAA | |
| SCHEMBL15884297 | 0.74 | SMN1; SMN2 (0.33) | SMN1; SMN2NPC1RAB9AATMNPSR1 | |
| SCHEMBL38660711 | 0.74 | MEN1 (0.42) | MEN1KMT2A | |
| SCHEMBL38659175 | 0.72 | TSHR (0.47) | SMN1; SMN2NPC1RAB9AATMMEN1 | |
| SCHEMBL25826800 | 0.72 | POLB (0.33) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL21835462 | 0.71 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9AATMGAA | |
| SCHEMBL15883822 | 0.70 | ALDH1A1 (0.35) | SMN1; SMN2NPC1RAB9AATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133375-A1 | MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2023-07-13 | — | — | WO | disclosed |