Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A3 | P38919 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26141147 | 0.88 | EIF4A3 (0.36) | EIF4A3GABRA1GABRB2 | |
| SCHEMBL20883918 | 0.80 | SIGMAR1 (0.36) | EIF4A3 | |
| SCHEMBL20883919 | 0.80 | PNMT (0.42) | EIF4A3 | |
| SCHEMBL27358232 | 0.76 | PTPN2 (0.41) | EIF4A3 | |
| SCHEMBL12546105 | 0.75 | EIF4A3 (0.32) | EIF4A3 | |
| SCHEMBL14803984 | 0.73 | EIF4A3 (0.32) | EIF4A3 | |
| SCHEMBL14804096 | 0.73 | KIF11 (0.43) | EIF4A3 | |
| SCHEMBL15785383 | 0.73 | HTR2C (0.37) | EIF4A3 | |
| SCHEMBL15785388 | 0.73 | EIF4A3 (0.34) | EIF4A3 | |
| SCHEMBL27358363 | 0.72 | POLB (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125841-A1 | HETEROCYCLIC COMPOUND AS POLθ INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2023-07-06 | — | — | WO | disclosed |