SCHEMBL25830853

SCHEMBL25830853

C=CC(=O)OCCc1ccc(N(c2ccc(-c3ccccc3)cc2)c2ccc(C)c(C)c2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 2/20 0.42
HCAR2 Q8TDS4 1/20 0.40
AKR1B10 O60218 5/20 0.38
AKR1B1 P15121 5/20 0.38
MGLL Q99685 1/20 0.37
ALOX5 P09917 3/20 0.36
TTR P02766 3/20 0.36
MMP12 P39900 1/20 0.36
APP P05067 2/20 0.36
CYP3A4 P08684 2/20 0.36
ALOX15 P16050 2/20 0.36
ALOX12 P18054 2/20 0.36
MAPK1 P28482 2/20 0.36
HSD17B10 Q99714 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
GMNN O75496 1/20 0.36
ALDH1A1 P00352 1/20 0.36
EGFR P00533 1/20 0.36
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1629356 0.96 THRB (0.40) THRBHCAR2AKR1B10AKR1B1APP
SCHEMBL12039127 0.94 THRB (0.41) THRBAKR1B10AKR1B1MGLLALOX5
SCHEMBL12144663 0.92 THRB (0.38) THRBHCAR2AKR1B10AKR1B1HSD17B10
SCHEMBL1629357 0.92 THRB (0.43) THRBHCAR2AKR1B10AKR1B1APP
SCHEMBL2609790 0.92 THRB (0.43) THRBHCAR2AKR1B10AKR1B1APP
SCHEMBL12214253 0.90 THRB (0.51) THRBHCAR2AKR1B10AKR1B1MGLL
SCHEMBL13777501 0.89 THRB (0.41) THRBCYP3A4MEN1ALDH1A1MAPT
SCHEMBL14195367 0.89 THRB (0.36) THRBHCAR2CYP3A4HSD17B10ALDH1A1
SCHEMBL26531990 0.89 RAB9A (0.40) THRBHCAR2MMP12ALDH1A1LMNA
SCHEMBL25445750 0.89 THRB (0.49) THRBHCAR2AKR1B10AKR1B1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12032318-B2 Electrophotographic image forming system with cleaning blade Konica Minolta, Inc. (JP) 2024-07-09 US disclosed
US-12032318-B2 Electrophotographic image forming system with cleaning blade Konica Minolta, Inc. (JP) 2024-07-09 US disclosed
US-20230185227-A1 ELECTROPHOTOGRAPHIC IMAGE FORMING SYSTEM Konica Minolta, Inc. (JP) 2023-06-15 US disclosed
US-20230185227-A1 ELECTROPHOTOGRAPHIC IMAGE FORMING SYSTEM Konica Minolta, Inc. (JP) 2023-06-15 US disclosed