Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 5/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.38 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1430018 | 0.78 | PSMB5 (0.41) | ALOX12ALOX15IMPDH2IMPDH1POLB | |
| SCHEMBL25832160 | 0.76 | CYP19A1 (0.55) | PBRM1KDM4EACHECYP19A1KMT2A | |
| SCHEMBL7940690 | 0.76 | MAOB (0.56) | ALOX12ALOX15IMPDH2IMPDH1CYP3A4 | |
| SCHEMBL29756799 | 0.73 | MAOB (0.45) | ALOX12ALOX15IMPDH2IMPDH1POLB | |
| SCHEMBL20165228 | 0.73 | MAOB (0.45) | ALOX12ALOX15IMPDH2IMPDH1POLB | |
| SCHEMBL25832172 | 0.72 | CYP19A1 (0.54) | PBRM1ARALDH1A1MAPTPKM | |
| SCHEMBL14741423 | 0.70 | PBRM1 (0.53) | PBRM1ARCYP19A1MAOB | |
| SCHEMBL31546010 | 0.66 | PTPN1 (0.41) | ALOX12ALOX15ALOX15BCYP3A4CYP19A1 | |
| Hydrochloric Acid SCHEMBL11337948 | 0.66 | IMPDH2 (0.44) | ALOX12ALOX15IMPDH2IMPDH1PBRM1 | |
| SCHEMBL21360079 | 0.65 | ALOX12 (0.35) | ALOX12ALOX15ALOX15BPBRM1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702427-B2 | Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same | ARBUTUS BIOPHARMA CORPORATION (CA) | 2023-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702427-B2 | Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same | HAVCR2, HPD, CYP24A1 | ALOX12 2514/4885ALOX15 2204/4885IMPDH2 359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.