Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9465836 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KMT2AUSP2LMNACYP1A2 | |
| SCHEMBL7166167 | 0.83 | GAA (0.49) | ALDH1A1KMT2AUSP2LMNACYP1A2 | |
| SCHEMBL25832179 | 0.82 | POLB (0.41) | ALDH1A1KMT2ALMNAPKMCYP3A4 | |
| SCHEMBL6799397 | 0.80 | NPC1 (0.45) | KMT2ACYP1A2TSHRSMN1; SMN2GAA | |
| SCHEMBL444879 | 0.79 | MAPK1 (0.56) | ALDH1A1KMT2AUSP2LMNACYP1A2 | |
| SCHEMBL11821060 | 0.78 | ACAT2 (0.37) | ALDH1A1KMT2ACYP1A2SMN1; SMN2PKM | |
| Gabapentin SCHEMBL3165631 | 0.76 | ALDH1A1 (0.54) | ALDH1A1KMT2AUSP2LMNACYP1A2 | |
| SCHEMBL14279001 | 0.75 | CYP3A4 (0.41) | KMT2ATSHRSMN1; SMN2PKMHPGD | |
| SCHEMBL12584974 | 0.75 | MAPK1 (0.72) | ALDH1A1KMT2AUSP2TSHRMAPK1 | |
| SCHEMBL7298836 | 0.73 | ALDH1A1 (0.58) | ALDH1A1KMT2AUSP2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702427-B2 | Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same | ARBUTUS BIOPHARMA CORPORATION (CA) | 2023-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702427-B2 | Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same | HAVCR2, HPD, CYP24A1 | ALDH1A1 2445/4885KMT2A 1259/4885USP2 4191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.