Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10162939 | 0.84 | EPHX2 (0.45) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL13496391 | 0.82 | NPC1 (0.46) | NPC1RAB9AMAPK1SMN1; SMN2LMNA | |
| SCHEMBL6789942 | 0.80 | IDO1 (0.58) | IDO1DAOPDE2A | |
| SCHEMBL19347692 | 0.80 | RAB9A (0.49) | NPC1RAB9AMAPK1SMN1; SMN2LMNA | |
| SCHEMBL19965714 | 0.78 | MAPK1 (0.43) | NPC1RAB9AMAPK1SMN1; SMN2LMNA | |
| SCHEMBL21561726 | 0.77 | MAPK1 (0.46) | NPC1RAB9AMAPK1SMN1; SMN2LMNA | |
| SCHEMBL13882014 | 0.77 | ESR1 (0.46) | NPC1RAB9AMAPK1SMN1; SMN2LMNA | |
| SCHEMBL4825997 | 0.77 | NPC1 (0.44) | NPC1RAB9AMAPK1SMN1; SMN2LMNA | |
| SCHEMBL20033747 | 0.77 | NPC1 (0.42) | NPC1RAB9AMAPK1SMN1; SMN2LMNA | |
| SCHEMBL18649029 | 0.77 | MAPK1 (0.42) | NPC1RAB9AMAPK1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122298-A1 | PROTEIN STABILIZING COMPOUNDS CONTAINING USP28 AND/OR USP25 TARGETING LIGANDS | Stablix, Inc. (US) | 2023-06-29 | — | — | WO | disclosed |