Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 5/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9177101 | 0.81 | MAPK1 (0.40) | RAB9AMAPK1NPC1SMN1; SMN2LMNA | |
| SCHEMBL16245761 | 0.81 | MAPK1 (0.41) | RAB9AMAPK1NPC1SMN1; SMN2LMNA | |
| SCHEMBL9154408 | 0.80 | RAB9A (0.48) | RAB9AMAPK1NPC1SMN1; SMN2LMNA | |
| SCHEMBL21561726 | 0.80 | MAPK1 (0.46) | RAB9AMAPK1NPC1SMN1; SMN2LMNA | |
| SCHEMBL25833534 | 0.80 | NPC1 (0.46) | RAB9AMAPK1NPC1SMN1; SMN2LMNA | |
| SCHEMBL20811730 | 0.79 | DAO (0.40) | ESR1ESR2AREPHX2RXRA | |
| SCHEMBL20811702 | 0.79 | DAO (0.40) | ESR1ESR2AREPHX2RXRA | |
| SCHEMBL11394368 | 0.78 | LMNA (0.45) | RAB9AMAPK1NPC1SMN1; SMN2LMNA | |
| SCHEMBL12603811 | 0.77 | DAO (0.51) | ESR1ESR2MAPTMEN1KMT2A | |
| SCHEMBL4399352 | 0.76 | ESR1 (0.72) | RAB9AMAPK1NPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156179-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |