Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25842059 | 0.81 | LMNA (0.40) | LMNAMAPTALDH1A1NLRP3 | |
| SCHEMBL20698988 | 0.81 | ALDH1A1 (0.41) | LMNAMAPTALDH1A1NLRP3 | |
| SCHEMBL22775438 | 0.79 | ALDH1A1 (0.40) | LMNAMAPTALDH1A1NLRP3 | |
| SCHEMBL25842048 | 0.79 | NLRP3 (0.31) | ALDH1A1NLRP3 | |
| SCHEMBL19475241 | 0.74 | RXRB (0.42) | LMNAMAPTALDH1A1NLRP3 | |
| SCHEMBL21962939 | 0.73 | ALDH1A1 (0.41) | LMNAMAPTALDH1A1NLRP3 | |
| SCHEMBL24674175 | 0.73 | ALDH1A1 (0.38) | LMNAMAPTALDH1A1NLRP3 | |
| SCHEMBL8255294 | 0.73 | LMNA (0.49) | LMNAMAPTALDH1A1NLRP3 | |
| SCHEMBL21962133 | 0.72 | RXRB (0.40) | LMNAMAPTALDH1A1NLRP3 | |
| SCHEMBL29927476 | 0.72 | NLRP3 (0.40) | LMNAMAPTALDH1A1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880666-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-06-28 | — | — | EP | disclosed |