SCHEMBL25835284

SCHEMBL25835284

O=c1[nH]c2c(ccc3[nH]c4ccc(-c5ccccc5)cc4c32)c2cc3c(cc12)[nH]c1ccc(-c2ccccc2)cc13

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 2/20 0.47
CCND1 P24385 2/20 0.47
GABRA1 P14867 3/20 0.44
GABRG2 P18507 3/20 0.44
GABRB3 P28472 3/20 0.44
GABRA5 P31644 3/20 0.44
GABRA3 P34903 3/20 0.44
GABRA2 P47869 3/20 0.44
GABRA6 Q16445 3/20 0.44
GABRA4 P48169 2/20 0.44
GABRP O00591 1/20 0.44
GABRD O14764 1/20 0.44
GABRB1 P18505 1/20 0.44
GABRB2 P47870 1/20 0.44
GABRE P78334 1/20 0.44
GABRG1 Q8N1C3 1/20 0.44
GABRG3 Q99928 1/20 0.44
GABRQ Q9UN88 1/20 0.44
TNKS2 Q9H2K2 1/20 0.43
FEN1 P39748 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25835282 0.86 TNKS2 (0.45) CDK4CCND1GABRA1GABRG2GABRB3
SCHEMBL25836916 0.85 GABRP (0.64) CDK4CCND1GABRA1GABRG2GABRB3
SCHEMBL25835161 0.85 GABRP (0.64) CDK4CCND1GABRA1GABRG2GABRB3
SCHEMBL16990946 0.84 GABRA1 (0.61) CDK4CCND1GABRA1GABRG2GABRB3
SCHEMBL16990932 0.82 GABRA1 (0.62) CDK4CCND1GABRA1GABRG2GABRB3
SCHEMBL15055611 0.76 CDK4 (0.67) CDK4CCND1GABRA1GABRG2GABRB3
SCHEMBL25836018 0.76 AHR (0.58) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL25836121 0.76 AHR (0.58) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL12181005 0.75 AHR (0.62) CDK4CCND1GABRA1GABRG2GABRB3
SCHEMBL15990082 0.75 TNKS2 (0.54) CDK4CCND1GABRA1GABRG2GABRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023110742-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2023-06-22 WO disclosed