Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12090712 | 0.77 | KDM4E (0.50) | NOTUMPRMT5WDR77CHEK1ALDH1A1 | |
| SCHEMBL20772757 | 0.74 | PARP1 (0.42) | NOTUMPRMT5WDR77CHEK1GSK3A | |
| SCHEMBL16439323 | 0.74 | CHEK1 (0.45) | NOTUMCHEK1SCN5A | |
| SCHEMBL22597503 | 0.73 | NOTUM (0.37) | NOTUMCHEK1SCN5AALDH1A1KDM4E | |
| SCHEMBL21025997 | 0.73 | TDP1 (0.43) | NOTUMPRMT5WDR77CHEK1GSK3A | |
| SCHEMBL22006722 | 0.73 | ADORA3 (0.42) | ADORA3ADORA1 | |
| SCHEMBL25835486 | 0.71 | GPR139 (0.46) | ADORA3GPR139ADORA1 | |
| SCHEMBL25338944 | 0.70 | LTK (0.33) | NOTUMCHEK1SCN5A | |
| SCHEMBL23057535 | 0.70 | CYP1A2 (0.44) | CYP1A2NOTUMSCN5AGAA | |
| SCHEMBL20772415 | 0.70 | NOTUM (0.37) | NOTUMPRMT5WDR77CHEK1SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023137356-A1 | 15-PGDH INHIBITORS | VENTYX BIOSCIENCES, INC. (US) | 2023-07-20 | — | — | WO | disclosed |