Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11379919 | 0.67 | ESR1 (0.43) | NPSR1KDM4EALOX15TSHRMAPK1 | |
| SCHEMBL11510982 | 0.64 | SMN1; SMN2 (0.50) | NPSR1EP300TSHRMAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11378680 | 0.64 | ALDH1A1 (0.47) | ALOX15TSHRMAPK1ALDH1A1GAA | |
| SCHEMBL22290242 | 0.62 | LOXL2 (0.38) | KDM4EMAPK1ALDH1A1LMNAGAA | |
| SCHEMBL28477056 | 0.61 | MAPK1 (0.49) | MAPK1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL29089722 | 0.61 | MAPK1 (0.53) | L3MBTL1TSHRMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20333678 | 0.60 | MAPK9 (0.40) | NPSR1KDM4EALDH1A1SMN1; SMN2HCAR1 | |
| SCHEMBL515186 | 0.60 | MAPT (0.56) | ALDH1A1LMNASMN1; SMN2MAPTNPC1 | |
| SCHEMBL14204025 | 0.59 | FGFR1 (0.36) | EP300KDM4EALDH1A1LMNAGAA | |
| SCHEMBL6518759 | 0.59 | CYP2C9 (0.58) | L3MBTL1KDM4EALOX15TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230202990-A1 | CYCLOHEXYL SUBSTITUTED TRIAZOLES | HOFFMANN-LA ROCHE INC. (US) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230202990-A1 | CYCLOHEXYL SUBSTITUTED TRIAZOLES | AVPR1A, AVPR1B, AVPR2 | NPSR1 16/4885EP300 1862/4885L3MBTL1 1157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.