Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.36 |
| ▸ | PNPO | Q9NVS9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 2/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26158321 | 0.86 | ESR1 (0.39) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL25020716 | 0.81 | ESR1 (0.39) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL25834986 | 0.81 | ESR1 (0.36) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL25836189 | 0.80 | ESR1 (0.35) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL29753770 | 0.79 | ADORA3 (0.37) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL25833602 | 0.79 | ESR1 (0.34) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL23692294 | 0.78 | TACR1 (0.35) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL23084662 | 0.77 | CHRM2 (0.33) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL25943764 | 0.76 | CASP3 (0.33) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL23692295 | 0.75 | ESR1 (0.32) | ESR1PTGS1ACP1PDE4AP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4209483-A1 | PRODRUG MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2023-07-12 | — | — | EP | disclosed |