Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PNPO | Q9NVS9 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25833602 | 0.81 | ESR1 (0.34) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL25834986 | 0.80 | ESR1 (0.36) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL25020716 | 0.80 | ESR1 (0.39) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL26158321 | 0.80 | ESR1 (0.39) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL25836189 | 0.77 | ESR1 (0.35) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL29753770 | 0.76 | ADORA3 (0.37) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL25836186 | 0.75 | ESR1 (0.36) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL23692294 | 0.75 | TACR1 (0.35) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL25943764 | 0.73 | CASP3 (0.33) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL22624265 | 0.72 | GAA (0.34) | ESR1PTGS1ACP1PDE4AP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210230195-A1 | PRODRUG MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC | 2021-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230195-A1 | PRODRUG MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ESR1 220/4885PTGS1 187/4885ACP1 4031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.