SCHEMBL25837294

SCHEMBL25837294

CN1/C(=C/C=C2\CCC(/C=C/C3=[N+](C)c4ccc(C(=O)Nc5ccccc5)cc4C3(C)C)=C2N(c2ccccc2)c2ccccc2)C(C)(C)c2cc(C(=O)Nc3ccccc3)ccc21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 13/20 0.37
KMT2A Q03164 9/20 0.37
HTT P42858 9/20 0.37
LMNA P02545 8/20 0.37
MEN1 O00255 7/20 0.37
KDM4E B2RXH2 6/20 0.37
ALDH1A1 P00352 6/20 0.37
SMN1; SMN2 Q16637 6/20 0.37
THRB P10828 5/20 0.37
TDP1 Q9NUW8 5/20 0.37
NPC1 O15118 4/20 0.37
POLB P06746 4/20 0.37
RAB9A P51151 4/20 0.37
PKM P14618 3/20 0.37
XBP1 P17861 3/20 0.37
ALOX12 P18054 3/20 0.37
S1PR4 O95977 2/20 0.37
ALPG P10696 2/20 0.37
S1PR1 P21453 2/20 0.37
NTSR1 P30989 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25837292 0.93 MAPT (0.38) MAPTKMT2AHTTLMNAMEN1
SCHEMBL14363977 0.91 HTT (0.38) MAPTKMT2AHTTLMNAMEN1
SCHEMBL13476159 0.91 HTT (0.38) MAPTKMT2AHTTLMNAMEN1
SCHEMBL25862060 0.91 HTT (0.38) MAPTKMT2AHTTLMNAMEN1
SCHEMBL14363973 0.90 MAPT (0.49) MAPTKMT2AHTTLMNAMEN1
SCHEMBL25837290 0.90 LMNA (0.37) MAPTKMT2AHTTLMNAMEN1
SCHEMBL25837284 0.89 HTT (0.39) MAPTKMT2AHTTLMNAMEN1
SCHEMBL25862055 0.89 MAPT (0.38) MAPTKMT2AHTTLMNAMEN1
SCHEMBL26682569 0.88 LMNA (0.36) MAPTKMT2AHTTLMNAMEN1
SCHEMBL14363983 0.87 MAPT (0.41) MAPTKMT2AHTTLMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230226814-A1 ON-PRESS DEVELOPMENT TYPE LITHOGRAPHIC PRINTING PLATE PRECURSOR, METHOD OF PREPARING LITHOGRAPHIC PRINTING PLATE, AND LITHOGRAPHIC PRINTING METHOD FUJIFILM CORPORATION (JP) 2023-07-20 US disclosed
US-20230219336-A1 ON-PRESS DEVELOPMENT TYPE LITHOGRAPHIC PRINTING PLATE PRECURSOR, METHOD OF PREPARING LITHOGRAPHIC PRINTING PLATE, AND LITHOGRAPHIC PRINTING METHOD FUJIFILM CORPORATION (JP) 2023-07-13 US disclosed
US-20230127702-A1 ON-PRESS DEVELOPMENT TYPE LITHOGRAPHIC PRINTING PLATE PRECURSOR, METHOD OF PREPARING LITHOGRAPHIC PRINTING PLATE, AND LITHOGRAPHIC PRINTING METHOD FUJIFILM CORPORATION (JP) 2023-04-27 US disclosed