Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BPTF | Q12830 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 3/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11038159 | 0.80 | ALDH1A1 (0.41) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL13091633 | 0.78 | KDM4E (0.40) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL21567337 | 0.74 | NOTUM (0.40) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL25119554 | 0.73 | BCL2L1 (0.42) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL28308270 | 0.72 | KDM4E (0.48) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL29479151 | 0.71 | ALDH1A1 (0.34) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL24373453 | 0.71 | ALDH1A1 (0.34) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL8255373 | 0.71 | MAPT (0.40) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL19869343 | 0.71 | NLRP3 (0.32) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL9748738 | 0.71 | MAPK1 (0.45) | KDM4EALDH1A1MAPTHPGDAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880666-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-06-28 | — | — | EP | disclosed |