Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 2/20 | 0.53 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.52 |
| ▸ | VCP | P55072 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2583200 | 0.88 | SLC2A1 (0.53) | SLC2A1VCPMAPTMAPK1NPSR1 | |
| SCHEMBL1353218 | 0.84 | SLC2A1 (0.63) | SLC2A1VCPMAPTMAPK1NPSR1 | |
| SCHEMBL2583209 | 0.82 | SOS1 (0.72) | SLC2A1SOS1MAPTMAPK1NPSR1 | |
| SCHEMBL2590586 | 0.82 | SLC2A1 (0.73) | SLC2A1SOS1KDM4ELMNAPDE5A | |
| SCHEMBL2587500 | 0.82 | SLC2A1 (0.65) | SLC2A1SOS1MAPTMAPK1NPSR1 | |
| SCHEMBL12176174 | 0.81 | VCP (0.51) | SLC2A1VCPMAPK1LMNASMN1; SMN2 | |
| SCHEMBL2590464 | 0.81 | SLC2A1 (0.66) | SLC2A1SOS1MAPTMAPK1NPSR1 | |
| SCHEMBL2585006 | 0.80 | PDE5A (0.60) | SLC2A1VCPMAPK1LMNASMN1; SMN2 | |
| SCHEMBL2592287 | 0.79 | SOS1 (0.71) | SLC2A1SOS1MAPTNPSR1KDM4E | |
| SCHEMBL15444680 | 0.79 | VCP (0.52) | SLC2A1VCPMAPK1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566480-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | California Institute of Technology (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |