Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 8/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24076903 | 0.81 | PRMT5 (0.48) | CHEK1PIM1RPS6KA3PRMT5WDR77 | |
| SCHEMBL24000186 | 0.81 | CHEK1 (0.44) | CHEK1PARP1PIM1RPS6KA3PRMT5 | |
| SCHEMBL25430355 | 0.79 | LMNA (0.46) | CHEK1PARP1PRMT5WDR77ATM | |
| SCHEMBL2460305 | 0.79 | CHEK1 (0.42) | CHEK1PARP1PIM1RPS6KA3PRMT5 | |
| SCHEMBL24076879 | 0.78 | DAO (0.38) | PRMT5WDR77ATMNPC1RAB9A | |
| SCHEMBL26733288 | 0.78 | KDM4E (0.57) | PRMT5WDR77NPSR1AR | |
| SCHEMBL25839255 | 0.78 | CHEK1 (0.44) | CHEK1PARP1PIM1RPS6KA3PRMT5 | |
| SCHEMBL27384927 | 0.76 | PARP1 (0.42) | CHEK1PARP1PIM1RPS6KA3PRMT5 | |
| SCHEMBL24076247 | 0.76 | PRMT5 (0.49) | PARP1PRMT5WDR77AR | |
| SCHEMBL31584704 | 0.76 | MAP2K4 (0.53) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230202989-A1 | COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230202989-A1 | COMPOUNDS | NLRP3, NLRP1, IL1B | CHEK1 3950/4885PARP1 403/4885PIM1 1748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.